The lyophilized solid lipid nanoparticles (SLN) loaded with all-trans retinoic acid were prepared using different cryoprotectants.

• 选用不同辅料作为冻干保护剂,制备维甲酸固体脂质纳米粒冻干品,并考察不同制品的外观、粒径、包封率。