The latest advance of study for PPK is to analyze the effect on AEDs due to CYP450 gene polymorphisms, and to choose different initial doses according to gene polymorphisms. It will be valuable to facilitate individualized dosage regimen.

• 目前,已有研究将CYP450基因多态性的因素引入群体药代动力学的模型,将其对抗癫痫药物代谢的影响进行了量化,并且,可以依据不同的基因型选择不同的初始剂量,促进个体化治疗,取得了新的进展。