The increased UNG2 in HIV-1 infected cells may lead to weakening Th cell function by decreasing TCR diversity,and may benefit incorporation of this enzyme into HIV-1 particles.

• HIV-1感染导致的UNG2表达上调,可能通过减少TCR的多样性削弱Th的功能,另一方面可能有利于病毒对UNG2的包装。