The human vaccinia virus B1R kinase related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

• 人类牛痘病毒B1R激酶相关激酶VRK1可使肿瘤抑制蛋白p53的Ser18磷酸化，该位点正是mdm-2的结合位点。