The high frontal amyloid load detected by [11C]PIB-PET in AD in the face of spared glucose metabolism is of interest and suggests that amyloid plaque formation may not be directly responsible for neuronal dysfunction in this disorder.

• 额叶较高的淀粉样蛋白沉积却不伴有相应的脑葡萄糖代谢率下降提示其对神经元退变影响的非直接作用。