The feeding of low antigen doses leads to induction of regulatory cell secretion of immunosuppressive cytokines,whereas higher doses favor clonal deletion and anergy.

• 低剂量口服抗原主要通过调节性T细胞分泌抑制性细胞因子介导免疫抑制,高剂量口服抗原主要引起T细胞清除或T细胞失能。