The expression of p16 and Rb protein were significantly correlated with the Dukes staging,especially with stage B.Conclusionp16 and Rb protein make a negative regulation in the P16/CDK/cyclinD/Rb/E 2F pathway.

• p16蛋白与Rb蛋白表达与Dukes分期显著相关 ,B期表达较C、D期为高。