The expression of c-myc was not significant different in SW116 and Colo-320 cells treated by 5-aza-dC. Conclusion The expression of p16 INK4A and APC genes was regulated by DNA methylation in three human colon cancer cells.

• 结论 三株人结肠癌细胞中 ,5 aza dC均可诱导 p16 INK4A和APC的表达 ,但对 p2 1WAF1和c myc无明显影响。