The expression change of BOULE gene or the absence of BOULE protein brings on meiosis arrest and spermatogenic failure, which can lead to azoospermia and male infertility.

• BOULE基因表达的改变或BOULE蛋白的缺乏可引起减数分裂阻滞和精子生成障碍；从而导致无精子症并产生不育.