The epitope inducing neutralizing antibody in high variable region 1 (HVR1) is the reason for escape of host immune surveillance, evolution of chronic infection, and also difficulty of producing wide spectrum vaccine.

• 由于诱导中和抗体的抗原表位恰好位于其包膜抗原E2蛋白的高变区 1(HVR1) ,因而容易逃避机体的免疫监视 ,形成慢性感染 ,同时造成发展广谱预防性疫苗的困难。