The employment of cyclin E and Ki67 in combination for the primary screening of cervical cytology could not only reduce both the higher false-positive and false-negative rate of conventional Pap test, but increase its specificy and sensitivity.

• 采用宫颈脱落细胞检测cyclin E、Ki67作为辅助诊断指标应用于宫颈癌高危人群筛查,具有重要意义。