The effect of soluble and fibrillar Aa 1-40 on the membrane permeability was assessed by measuring the re-l ease of vesicle-entrapped with three different molecular weight fluoresc ence probes (ANTS/DPX, Calcein, FD-4).

• 用三种水溶性的分子质量不同的荧光探剂ANTS/DPX,Calcein,DextranFD-4包裹在脂质体内,检测可溶的和纤维化的A茁1-40对其内含物漏出的影响。