The directional biotransformation of curcumol(1) by Penicillium janthinellum was studied.The metabolite(2) was isolated by silica gel column chromatography and purified by recrystallization.

• 使用微紫青霉对莪术醇(1)进行生物转化,采用硅胶柱色谱法从发酵液的乙酸乙酯萃取层中分离得到转化产物(2),利用理化及各种光谱手段鉴定其结构为15-羟基莪术醇。