The development of congenital anorectal malformations closely relates to the de creased expression of Gli2 gene, and aberration in signaling is responsible for ETU-induced malformations. J Appl Clin Pediatr,2005,20(2):180-182

• Gli2基因表达水平减低与先天性无肛畸形的发生密切相关 ,乙烯硫脲致畸机制之一是影响Shh信号转导系统。