The decrease of iNOS and eNOS in placental villus may be one of the causes for fetal distress and premature labor in ICP.

• ICP患者胎盘绒毛组织iNOS和eNOS表达降低,可能导致胎儿-胎盘循环阻力升高,是ICP患者发生胎儿宫内窘迫和早产的原因之一。