The critical technology in producing ODTs is the technology to make them disintegrate rapidly. Lyophilization or freeze-drying, direct compression and compression after wet granulation are currently applied home and abroad.

• 冷冻干燥压片将主药和辅料定量分装在一定模具中，冻干去水，制得高孔隙率的固体制剂，其质地疏松，崩解时限一般在15秒内。