The costimulatory signal mediated by 4-1BB molecule could mainly induce the proliferative response of CD8 + T cells, while that mediated by CD28 molecule could induce the activation of CD4 + T cells mainly.

• 4 1BB分子所介导的协同刺激信号 ,在CD8+ T细胞活化及增殖中发挥了更为重要的作用 ; 而CD2 8分子所介导的协同刺激信号则更有利于CD4 + T细胞的活化