The chromosome caryotypes of cell strains in adenocarcinoma of lungsuch as A594, A594/CDDP, SPC-A-1 and SPC-A-1/CDDP were sub-triploid. More chromosome breakages and reconstructions were found aller carcinomacel1s had been induced to drug resistance.

• 肺腺癌细胞株A549、A549/CDDP、SPC-A-1及SPC-A-1/CDDP的染色体核型均为亚三倍体，癌细胞在诱导耐药后出现了较多的染色体断裂和重组。