The changes of 8-OH-dG in the progress of carcinogenesis were detected in human bronchial epithelial cells induced by Benzo(a)pyrene diol-epoxide(BPDE)and sulfide nickel(NiS) in vitro.

• 并利用苯并 (a)芘代谢产物B(a)P 二醇 环氧化物 (BPDE)和结晶型硫化镍 (NiS)诱导的体外人支气管上皮细胞转化癌变模型 ,检测癌变进程中 8 OH dG的变化。