The brain chemical corticotropin-releasing-factor, CRF, is linked to motivation, and plays a role in drug and alcohol withdrawal and relapse.

• 大脑内的化学物质促肾上腺皮质激素释放因子与动机有关，CRF与在戒毒和戒酒过程中出现的不适症状以及重染这些旧习也有关系。