The birth defect rate was highest among women who took Topamax in combination with the epilepsy drug valproate, which has been linked to birth defects in numerous studies and epilepsy databases.

• 在妥泰联用抗癫痫药丙戊酸盐的女性中出生缺陷发生率最高，后者已被许多研究结果和癫痫数据库认定与出生缺陷相关。