The average maximum excretion rate to DBand 4-OH-DB were both 1 .67 h which suggested the quick absorption andpresystemic metabolism of DB.

• 0559h~(-1)。 DB和4-0H-DB的最大平均排泄速率时间均为1.；67h；说明DB口服吸收迅速；并可能存在“体循环前代谢”。