The antibody of RAGE could inhibit the effects of AGEs on cytosolic free calcium transient in cardiac myocyts,which suggests that the effects of AGEs may be mediated by RAGE.

• 抗RAGE抗体可以阻断晚期糖基化终产物引起的心肌细胞胞内游离钙离子浓度升高,提示晚期糖基化终产物引起心肌细胞胞内游离钙离子浓度升高是由RAGE介导的。