The amino acid sequence of PACAP is extremely conserved across vertebrate species, indicating a strong functional constraint during the course of evolution.

• 前人的研究表明，该基因突变失活以后，会引发人类原发性小脑症，病人的脑容量仅有正常人的三分之一到四分之一，相当于早期类人猿的脑容量。