The SPC-A1/Docetaxel cell line showed high resistance to docetaxel, and had the characteristic of multidrug resistance. The cell line could be useful for the study of drug resistant mechanism and its reversal of docetaxel.

• 经体外诱导耐药建立的SPC-A1/Docetaxel表现出对多西他赛较高的耐药性,并呈多药耐药特性,耐药细胞系SPC-A1/Docetaxel与亲本细胞SPC-A1的生物学特性有明显差异,可用于对多西他赛的耐药机制和逆转耐药研究。