TRAIL-induced apoptosis is mediated through its death receptor DR5 or DR4.By binding to these receptors, TRAIL recruits an adaptor molecule FADD, and then activates caspase-8 to induce the apoptosis of cells.

• 其诱导肿瘤细胞凋亡是通过它的受体介导完成的，TRAIL与其特异受体(DR5或DR4)结合，募集Fas相关死亡域(FADD)，进而激活caspase-8，诱导肿瘤细胞凋亡。