Systemic lupus erythematosus(SLE) is prototype of autoimmune disease characterized by disfunction of T cell and B cell and the occurrence of numerous autoantibodies directed against nuclear antigens.

• 系统性红斑狼疮是自身免疫性疾病的原型,主要表现为T、B淋巴细胞功能异常,产生大量自身抗体,近年来发现,T细胞及其亚群和共刺激分子可能是SLE的发病机制的关键。