Sustained-release pellets were prepared by taking 4% Eurdrugit RS100, 10%PEG-400, 20%DEP, The loading formulation was optimized by orthogonal experiment and the accumulation release amount of 2hr,6hr and 10 hr as the evaluation target.

• 在制备药物树脂缓释微丸时，采用正交设计试验，以2、6、10小时的药物释放度作为评价指标，优化得到最佳包衣液处方：4%25RS100，10%25PEG400，20%25DEP； 以400r/min速度包衣，得缓释微丸。