Summary of Background Data.With current in io models for the study of disc and endplate degeneration, it remains difficult to inestigate the complex disc metabolism and signaling cascades.

• 背景数据的总结：目前在研究椎间盘和终板退化的体内模型中，观察复杂的椎间盘的代谢过程和信号级联放大过程是很困难的。