Stress-induced activation of the hypothalamus-pituitary-adrenal (HPA) axis and the consequent increase in plasma adrenocorticotropic hormone(ACTH) and glucocorticoid levels are dependent upon CRH.

• 应激诱导的HPA激活及随后血浆促肾上腺皮质激素（adrenocorticotropic hormone ，ACTH）及糖皮质激素（glucocorticoid ，GC）含量的升高均依赖于CRH。