Since AAV-hBMP4 can transfect rabbit BMSCs cultured in vitro at a high rate without significant effect on vitality of proliferated cells,rabhit BMSCs transfected with AAV-hBMP4 seem to be a favorable kind of seed cell for bone tissue engineering.

• AAV-hBMP4转染效率高,对BMSCs的增殖活性影响小,AAV-hBMP4转染的BMSCs可望成为组织工程化骨的理想种子细胞。