Several etiologic factors have been proposed for the development of LCINS, including exposure to radon, cooking fumes, asbestos, heavy metals, and environmental tobacco smoke, human papillomavirus infection, and inherited genetic susceptibility.

• 病因学认为氡、烹调产生的油烟、石棉、重金属、环境性吸烟、人类乳头瘤病毒的感染以及遗传易感性均是从这类人群发生肺癌的危险因素。