S.epi dermidis agr deletion mutant was successfully constructed, most of sequences o f S.epidermidis 3298-agr were replaced by erythromycin resistance gene.

• 用同源重组的方法完成表皮葡萄球菌 32 98 agr阴性突变株的构建 ,使agr基因被大部分剔除掉。