Rituximab,a monoclonal antibody directed against the CD20 antigen of B lymphocytes,has been demonstrated to be effective in recalcitrant and life-threatening pemphigus.

• 利妥昔单抗作为一种单克隆抗CD20抗体,近年来已被用于治疗顽固重症天疱疮患者,并取得满意疗效。