Reversing this accumulation may thus be valuable, but has proven challenging, doubtless because substances resistant to cellular catabolism are inherently hard to degrade.

• 因此，逆转这种积累可能是有价值的，但要逆转它被证明是挑战性的，无疑地是因为对细胞降解作用有抗性的这些物质本性就是难以降解的。