Retrograde afflection and abrade of cartilage, cirrhosis of substance of bone, cystic degeneration and articular transfiguration are the center of the osteoarthritis of knee in the last period.

• 后期软骨退变磨损，骨质硬化、退变、骨赘等形成，关节肥大变形，构成膝关节骨性关节炎的核心。