Results The clony efficiencies of rat peripheral blood lymphocytes and spleen lymphocytes both declined with the increase of accumulative dose,while the HPRT gene mutation frequency rose.

• 结果外周血淋巴细胞和脾淋巴细胞的克隆效率均随内照射剂量的增加而降低,HPRT基因突变频率均随放射性核素内照射剂量的增加而增加。相同条件下,脾淋巴细胞HPRT基因突变比外周血淋巴细胞敏感。