Recently established DHBV animal model can be used to study HBV infection and replication, it also acts as a convenient animal model to preliminarily screen the anti-HBV drug or method in vivo.

• 由于DNA疫苗可以诱发强有力的免疫反应尤其是细胞免疫反应以及细胞免疫反应在HBV持续感染中清除病毒的重要作用，故DNA疫苗作为一种新的针对HBV持续感染的治疗手段，近年来在各种动物模型及人体上开展了大量研究，显示出潜在的应用价值；