Recent p rogress in molecular and cellular biology as well as cytogenetic has shed light on the possible molecular mechanisms and their association with carcinogenesis.

• 本文从纺锤体检测点、多中心体、细胞周期检测点、DNA双链断裂、异常端粒、甲基化等角度综述了染色体不稳定性产生的可能分子机制,以及其与肿瘤发生的关系。