Recent data have demonstrated that the tails of histones H3 and H4 greatly reduce the speed of transcript elongation through a nucelosome, and tail acetylation suppresses this effect.

• 近来研究表明组蛋白尾部尤其是H3、H4四聚体的尾部强烈影响通过核小体的转录延伸速率，而尾部的乙酰化修饰可抑制这种影响。