Protists, often reproducing asexually in the wild, would gradually accumulate small mutations and genome rearrangements that would be crippling without a mechanism to mitigate the effect.

• 原生动物在野生条件下通常为无性繁殖，这一过程会逐渐积累小的突变并发生基因组重排，如果没有一种缓和机制的话，该过程最终会破坏基因组的稳定。