Protease-activated receptors 2 were strongly expressed on colon cancer cells,enhancing cell proliferation and migration as well as IL-8 production,which was closely associated with cancer metastasis and the malignant behavior.

• 蛋白酶激活受体2在结肠癌细胞表面大量表达,可增强细胞的增殖和迁移能力及IL-8的分泌,表明与肿瘤的转移能力及恶性程度密切相关。