Propafenone hydrochloride(1.HCl)was prepared from diethyl malonate and benzyl chloride,through condensation,cyclization,hydrolysis,ethe-rification,and amination in 20% overall yield.

• 由氯苄与丙二酸二乙酯经缩合、环合、水解、醚化、胺化合成盐酸普罗帕酮,总收率20%25。