PrP c was expressed in EBs from murine ESc and in EBs treated with VPA. The level of PrP c expression presented direct ratio with the DCF value, ROS and increasing concentration of VPA and its analoques(VPA-A, VPA-B, VPA-C).

• PrPc 在小鼠胚胎干细胞诱导分化形成的胚胎小体 (EBs)中有所表达 ；其表达水平与丙戊酸 (VPA)及其衍生物 (VPA -A ；VPA -B ；VPA -C)的DCF值、ROS产量以及VPA -E的浓度成正比 ；VPA及其衍生物可以使PrPc的表达上调 .