Polypeptide and protein microspheres can elevate drug availability, but drug devitalization and drug fast release can result in side effects during microsphere preparation.

• 多肽及蛋白类药物微球在提高药物的利用度的同时,存在的主要要问题是微球制备过程中药物失活及药物突释而产生的毒副作用。