Polyketide synthases catalyze the synthesis of complex natural products including macrolide antibiotics from simple precursors such as propionyl-CoA and methylmalonyl-CoA.

• 聚酮合成酶能够合成包括许多大环内酯类抗生素在内的聚酮类天然产物,它的结构和功能的模块性为组合生物合成的产生和发展奠定了基础。