Permeating skin accelerant laurocapram was synthesized in the presence of KF Al 2O 3 in high yield. The application of ultrasound leads to a decrease in reaction time remarkably.

• 以KF－Al2O3作为催化剂合成了皮肤渗透促进剂月桂氮?酮并得到高收率的产物，将超声波应用于该合成反应中使反应时间明显缩短。