Patients with squamous-cell tumors, brain metastases, clinically significant hemoptysis, or inadequate organ function or performance status (ECOG performance status, >1) were excluded.

• 排除以下类型的患者：鳞状上皮细胞癌、脑转移、临床显著咳血、器官功能不足或ECOG体力状态评分>1。