Pancreatic fibrosis was induced by intraperitoneal injection with diethyldithiocarbamate(DDC 750 mg/kg body weight)in rats.

• 以腹腔注射DDC(750mg/kg体重)每周2次,共6周建立胰腺纤维化动物模型,治疗组于DDC注射后2周起每日腹腔注射苦参碱(100mg/kg体重),6周后处死动物。