PGD_2 has been identified to be a sleep-inducing substance that becomes bound to the DP receptor (DPR) exclusively localized on the surface of the basal forebrain, leading to an increase in extracellular adenosine levels there.

• 研究表明PGD2具有睡眠调节作用,其机理为PGD2与前列腺素D2受体结合,升高基底前脑部位细胞外腺苷水平。